Publications | Clinical Cognitive Psychophysiology Lab

2026

Liebrand, M., Hamilton, H. K., Roach, B. J., Nicholas, S., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Perkins, D. O., Walker, E. F., Woods, S. W., Cannon, T. D., Thomas König, Mathalon, D. H. (in press). Electroencephalography microstates indicate reduced neural network stability and are associated with clinical outcome in patients at clinical high risk for psychosis. JAMA Psychiatry.

Rodriguez-Sanchez, J., Hauke, D. J., Pinotsis, D. Berndt, L. C. S., Oloye, H., Nicholas, S. C., Hamilton, H. K., Roach, B. J., Bachman, P. M., Belger, A., Carrión, R. E., Duncan, E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Friston, K. J., Addington, J., Bearden, C. E., Cadenhead, K. S., Perkins, D. O., Walker, E. F., Woods, S. W., Cannon, T. D., Adams, R. A., Mathalon, D. H. (2026). Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome: Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms. Biological Psychiatry. Online ahead of print. https://doi.org/ 10.1016/j.biopsych.2026.03.1008

Cecchi, M., Johannesen, J., Farley, B., Quirk, M. C., Mahmoud-Zedeh, M., Uslaner, J. M., Terry-Lorenzo, R., Smith, D. G., Ruhl, D. A., Rotte., M., Reese, A. L., O’Donnell, P., Mollon, J., Missling, C., Matsuoka, Y., Marino, M. J., Lee, S., Korolev, I. O., Klamer, D., Jeong, A., Honda, S., Fadem, K. C., Doherty, J., Cohen, E. A., Christensen, S., Chadchankar, H., Buhl, D. L., Adachi, M., D’Souza, D. C., Hamilton, H. K., Ranganathan, M., Roach, B. J., Ereschefsky, L., Walling, D. P., Potter, W. Z., Javitt, D. C., Mathalon, D. H. (in press). Baseline Mismatch Negativity amplitude predicts direction and magnitude of ketamine effect in healthy volunteers — A “disordinal” effect. Biological Psychiatry.

Donaldson, K. R., Hanson, J., Pokorny,V., Shen, C., Klein, S., Hamilton, H. K., Sponheim, S. R. (2026). Schizophrenia disrupts normative covariation of neural activity across modalities of perception. Journal of Psychopathology and Clinical Science. Online ahead of print. https://doi.org/10.1037/abn0001128

Yang, X., & ENIGMA Clinical High Risk for Psychosis Working Group [including Hamilton, H. K.]. (2026). Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis. Molecular Psychiatry. Online ahead of print. https://doi.org/10.1038/s41380-026-03586-4

Hamilton, H. K., Roach, B. J., Nicholas, S., Dembo, R., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Perkins, D. O., Walker, E. F., Woods, S. W., Cannon, T. D., & Mathalon, D. H. (2026). Visual P300 and risk for psychosis onset among individuals at clinical high-risk for psychosis. Biological Psychiatry. Online ahead of print. https://doi.org/10.1016/j.biopsych.2026.02.013

Hua, J. P. Y., Roach, B. J., Hamilton, H. K., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Perkins, D. O., Walker, E. F., Woods, S. W., Cannon, T. D., & Mathalon, D. H. (2026). Theta oscillations assessed from a passive auditory oddball paradigm in individuals at clinical high-risk for psychosis and healthy controls individuals: Associations with clinical outcomes and mismatch negativity. Biological Psychiatry Global Open Science, 6, 100664. https://doi.org/10.1016/j.bpsgos.2025.100664

Liu, S., & ENIGMA Clinical High Risk for Psychosis Working Group [including Hamilton, H. K.]. (2025). Structural Covariance Network Topology in Individuals at Clinical High Risk for Psychosis: the ENIGMA-CHR Study. Molecular Psychiatry 31, 1707-1722. Online ahead of print. https://doi.org/10.1038/s41380-025-03304-6

2025

Peled-Avron, L., Aday, J. S., Pantoni, M. M., Hamilton, H. K., Woolley, J. D. (2025). Acute effects of MDMA on empathy and emotion recognition: a meta-analysis of human studies. Scientific Reports, 15, 42955. https://doi.org/10.1038/s41598-025-25610-3

Carrion, R. E., John, M., Dorvil, S., Auther, A., McLaughlin, D., Arnovitz, M., Bachman, P., Belger, A., Duncan, E., Hamilton, H. K., Johannesen, J. K., Ku, B., Light, G. A., Niznikiewicz, M., Roach, B. J., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Keshavan, M., Perkins, D. O., Stone, W. S., Tsuang, M., Walker, E. F., Woods, S. W., Mathalon, D. H., Cornblatt, B. A. (2025). Exploring the pathways between early auditory processing, processing speed, social cognition, and negative symptoms on social functioning in individuals at clinical high risk for psychosis: A structural equation modeling approach. Biological Psychiatry. Online ahead of print. https://doi.org/10.1016/j.biopsych.2025.06.033

Ku, B., Hamilton, H. K., Yuan, Q., Parker, D. A., Roach, B.J., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., Keshevan, M., Perkins, D. O., Stone, W., Woods, S. W., Walker, E. F., & Mathalon, D. H. (2025). Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons. Neuropsychopharmacology, 50, 1446-1454. https://doi.org/10.1038/s41386-025-02093-4

Hamilton, H. K. & Mathalon, D. H. (2025). Neurophysiological models in individuals at clinical high risk for psychosis: Using translational EEG paradigms to forecast psychosis risk and resilience. In Javitt, D. & McPartland, J. (Eds.), Neurophysiologic biomarkers in neuropsychiatric disorders: Etiologic and treatment considerations. Springer. https://doi.org/10.1007/978-3-031-69491-2_14

Mathalon, D. H., Light, G. A., Nicholas, S., Billah, T., Lavoie, S., Whitford, T., Roach, B. J., Bouix, S., Hamilton, H. K., Pogarell, O., Anhokin, A., Jenni, R., Kerins, S., Lee, C., Dzafix, I., Belger, A., Wood, S., Kahn, R., McGorry, P., Kane, J., Bearden, C. E., Nelson, B., Woods, S. W., Shenton, M., Accelerating Medicines Partnership Schizophrenia (AMP SCZ). (2025). The electroencephalography protocol for the AMP SCZ consortium: Reliability and stability of measures. Schizophrenia, 11, 85. https://doi.org/10.1038/s41537-025-00622-0

Hamilton, H. K., Roach, B. J., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., Cannon, T. D., & Mathalon, D. H. (2025). Mismatch negativity as an index of auditory short-term plasticity: Associations with cortisol, inflammation, and gray matter volume in youth at clinical high-risk for psychosis. Clinical EEG & Neuroscience, 56, 46-59. https://doi.org/10.1177/15500594241294035

2024

Wannan, C. M. J., Nelson, B. J., & AMP SCZ Network [including Hamilton, H. K.]. (2024). Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and study design of the largest global prospective cohort study of clinical high risk for psychosis. Schizophrenia Bulletin, 50, 496-512. https://doi.org/10.1093/schbul/sbae011

Hamilton, H. K., Mathalon, D. H., & Ford, J. M. (2024). P300 in schizophrenia: Then and now. Biological Psychology, 187, 108757. https://doi.org/10.1016/j.biopsycho.2024.108757

Zhu, Y. & ENIGMA Clinical High Risk for Psychosis Working Group [including Hamilton, H. K.]. (2024). Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk. Molecular Psychiatry, 29, 1465-1477. https://doi.org/10.1038/s41380-024-02426-7

Peled-Avron, L., Kalafateli, A. L., Aday, J., Hamilton, H. K., & Woolley, J. (2024). Down the rabbit hole: Investigating the neurobiological and psychological mechanisms of psychedelic compounds. Frontiers in Psychiatry, 15, 1431389. https://doi.org/10.3389/fpsyt.2024.1431389

2023

Allen, P., Baldwin, H., Bartholomeusz, C. F., Chee, M. W. L., Chen, X., Cooper, R. E., de Haan, L., Hamilton, H. K., et al., & ENIGMA Clinical High Risk for Psychosis Working Group (2023). Normative modeling of brain morphometry in clinical high risk for psychosis. JAMA Psychiatry, 81, 77-88. https://doi.org/10.1001/jamapsychiatry.2023.3850

Banaj, N. Vecchio, D., Piras, F., De Rossi, P., Bustillo, J., Ciufolini, S., Dazzan, P., Di Forti, M., Dickie, E. W., Ford, J. M., Fuentes-Claramonte, P., Gruber, O., Guerrero-Pedraza, A., Hamilton, H. K., et al., & ENIGMA Clinical High Risk for Psychosis Working Group (2023). Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: A worldwide meta- and mega-analysis. Molecular Psychiatry, 28, 4363-4373. https://doi.org/10.1038/s41380-023-02221-w

2022

Hamilton, H. K., & Mathalon, D. H. (2022). Probing long-term potentiation-like visual cortical plasticity in humans using repeated visual stimulation: Effects on visual evoked potentials. Neuropsychopharmacology, 48, 217-218. https://doi.org/10.1038/s41386-022-01420-3

Duncan, E., Roach, B. J., Massa, N., Hamilton, H. K., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J. A., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Tsuang, M., Walker, E. F., Woods, S. W., Nasiri, N., Mathalon, D. H. (2022). Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort. Schizophrenia Research, 248, 89-97. https://doi.org/10.1016/j.schres.2022.07.019

Baldwin, H. & ENIGMA Clinical High Risk for Psychosis Working Group [including Hamilton, H. K.]. (2022). Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis. Translational Psychiatry, 12, 297. https://10.0.4.14/s41398-022-02057-y

Hamilton, H. K., Roach, B. J., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., Cannon, T. D., & Mathalon, D. H. (2022). Mismatch negativity in response to auditory deviance and the risk for future psychosis in clinical high-risk youth. JAMA Psychiatry, 79, 780-789. https://doi.org/10.1001/jamapsychiatry.2022.1417

2021

Jalbrzikowski, M., & ENIGMA Clinical High Risk for Psychosis Working Group [including Hamilton, H. K.] (2021). Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for developing psychosis: An ENIGMA Working Group mega-analysis. JAMA Psychiatry, 78, 573-766. https://doi.org/10.1001/jamapsychiatry.2021.0638

Jacob, M. S., Roach, B. J., Hamilton, H. K., Bachman, P. M, Belger, A., Carrion, R. E., Duncan, E. J., Johannesen, J. K., Light, G., Niznikiewicz, M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., & Mathalon, D. H. (2021). Visual cortical plasticity and the risk for psychosis: An interim analysis of the North American Prodrome Longitudinal Study. Schizophrenia Research, 230, 26-37. https://doi.org/10.1016/j.schres.2021.01.028

Foss-Feig, J. H., Guillory, S. B., Roach, B. J., Velthorst, E., Hamilton, H. K., Bachman, P. M, Belger, A., Carrion, R. E., Duncan, E. J., Johannesen, J. K., Light, G., Niznikiewicz, M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., & Mathalon, D. H. (2021). Abnormally large baseline P300 amplitude may predict conversion to psychosis in clinical high risk individuals with a history of autism: A pilot study. Frontiers in Psychiatry, 12, 591127. https://doi.org/10.3389/fpsyt.2021.591127

Hamilton, H. K., Roach, B. J., & Mathalon, D. H. (2021). Forecasting remission from the psychosis risk syndrome with mismatch negativity and P300: Potentials and pitfalls. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6, 178-187. https://doi.org/10.1016/j.bpsc.2020.10.010

2020

Hamilton, H. K., Roach, B. J., Cavus, I., Teyler, T., Clapp, W., Ford, J. M., Tarakci, E.,Krystal, J. H. & Mathalon, D. H. (2020). Impaired potentiation of theta oscillations during a visual cortical plasticity paradigm in individuals with schizophrenia. Frontiers in Psychiatry, 11, 590567. https://doi.org/10.3389/fpsyt.2020.5905

Roach, B. J., Carrion, R. E., Hamilton, H. K., Bachman, P. M, Belger, A., Duncan, E. J., Johannesen, J. K., Light, G., Niznikiewicz, M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., & Mathalon, D. H. (2020). Reliability of mismatch negativity event-related potentials in a multisite, traveling subjects study. Clinical Neurophysiology, 131, 2899-2909. https://doi.org/10.1016/j.clinph.2020.09.027

Hamilton, H. K., Boos, A., & Mathalon, D. H. (2020). Electrophysiological and event-related potential biomarkers in individuals at clinical high risk for psychosis. Biological Psychiatry, 88, 294-303. https://doi.org/10.1016/j.biopsych.2020.04.002

Fryer, S. L., Roach, B. J., Hamilton, H. K., Bachman, P. M., Belger, A., Carrion, R. E., Duncan, E. J., Johannesen, J. K., Niznikiewicz, M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., & Mathalon, D. H. (2020). Deficits in auditory predictive coding in individuals with the psychosis risk syndrome: Prediction of conversion to psychosis. Journal of Abnormal Psychology, 129, 599-611. https://doi.org/10.1037/abn0000513

Roach, B. J., Hamilton, H. K., Bachman, P. M, Belger, A., Carrion, R. E., Duncan, E. J., Johannesen, J. K., Light, G., Niznikiewicz, M., Addington, J., Bearden, C. E., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., & Mathalon, D. H. (2020). Stability of mismatch negativity event-related potentials in a multisite study. International Journal of Methods in Psychiatric Research, 29, e1819. https://doi.org/10.1002/mpr.1819

Reed, A. C., Lee, J., Green, M. F, Hamilton, H. K., Miller, G. A., Subotnik, K. L., Ventura, J., Nuechterlein, K. H., & Yee, C. M. (2020). Associations between physiological responses to social-evaluative stress and daily functioning in first-episode schizophrenia. Schizophrenia Research, 218, 233-239. https://doi.org/10.1016%2Fj.schres.2019.12.040

Ford, J. M., Hamilton, H. K., Llerena, K., Roach, B. J., & Mathalon, D. H. (2020). Neurophysiologic biomarkers of psychosis: Event-related potential biomarkers. In Tamminga, C. A., Ivleva, E. I., Reininghaus, U., & van Os, J. (Eds.), Psychotic disorders: Comprehensive conceptualization and treatments. Oxford University Press. https://doi.org/10.1093/med/9780190653279.003.0026

2019

Hamilton, H. K., Roach, B. J., Bachman, P. M., Belger, A., Carrion, R. E., Johannesen, J. K., Light, G. A., Niznikiewicz, M. A., Addington, J., Bearden, C. E., Cadenhead, K. S., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., Cannon, T. D., & Mathalon, D. H. (2019). Association between P300 responses to auditory oddball stimuli and clinical outcomes in the psychosis risk syndrome. JAMA Psychiatry, 76, 1187-1197. https://doi.org/10.1001/jamapsychiatry.2019.2135

Hamilton, H. K., Woods, S. W., Roach, B. J., Llerena, K., McGlashan, T. H., Srihari, V. H., Ford, J. M., & Mathalon, D. H. (2019). Auditory and visual oddball stimulus processing deficits in schizophrenia and the psychosis risk syndrome: Forecasting psychosis risk with P300. Schizophrenia Bulletin, 45, 1068-1080. https://doi.org/10.1093/schbul/sby167

Roach, B. J., Ford, J. M., Biagianti, B., Hamilton, H. K., Ramsay, I. S., Fisher, M., Loewy, R., Vinogradov, S., Mathalon, D. H. (2019). Efference copy/corollary discharge function improves with targeted cognitive training in patients with schizophrenia. International Journal of Psychophysiology, 145, 91-98. https://doi.org/10.1016/j.ijpsycho.2018.12.015

Ford, J. M., Hamilton, H. K., & Boos, A. (2019). Neurobiology of auditory hallucinations. Oxford Research Encyclopedia of Neuroscience: Sensory Systems. https://doi.org/10.1093/acrefore/9780190264086.013.311

Ford, J. M. & Hamilton, H. K. (2019). Are neuroanatomical abnormalities underlying hallucinations modality-specific? The Lancet: eClinical Medicine, 8, 8-9. https://doi.org/10.1016/j.eclinm.2019.01.013

Hamilton, H. K. & Simeon, D. (2019). Depersonalization/derealization disorder and schizotypal personality disorder. In A. Moskowitz, I. Shafer, & M. Dorahy (Eds.), Psychosis, dissociation, and trauma: Evolving perspectives on severe psychopathology. London: John Wiley & Sons. 2^nd Ed, revised from 1^st edition. https://doi.org/10.1002/9781118585948.ch15

2018

Hamilton, H. K., Williams, T. J., Ventura, J., Jasperse, L. J., Owens, E. M., Miller, G. A., Subotnik, K. L., Nuechterlein, K. H., & Yee, C. M. (2018). Clinical and cognitive significance of auditory sensory processing deficits in schizophrenia. American Journal of Psychiatry, 175, 275-283. https://doi.org/10.1176/appi.ajp.2017.16111203

Hamilton, H. K., Perez, V. B., Ford, J. M., Roach, B. J., Jaeger, J., & Mathalon, D. H. (2018). Mismatch negativity but not P300 is associated with functional disability in schizophrenia. Schizophrenia Bulletin, 44, 492-504. https://doi.org/10.1093/schbul/sbx104

Hamilton, H. K., D’Souza, D. C., Ford, J. M., Roach, B. J., Kort, N. S., Ahn, K. S., Bhakta, S., Ranganathan, M., & Mathalon, D. H. (2018). Interactive effects of an N-methyl D-aspartate glutamate receptor antagonist and a nicotinic acetylcholine receptor agonist on mismatch negativity: implications for schizophrenia. Schizophrenia Research, 191, 87-94. https://doi.org/10.1016/j.schres.2017.06.040

2017 and earlier

Miller, G. A., Rockstroh, B., Hamilton, H. K., & Yee, C. M. (2016). Psychophysiology as a core strategy in RDoC. Psychophysiology, 53, 410-414. https://doi.org/10.1111/psyp.12581

Goldstein, K. E., Berlin, H. A., Hamilton, H. K., Mitsis, E. M., McClure, M. M., Savage, K. R., Blair, N. J., Feder, M. R., Siever, L. J., New, A. S., & Hazlett, E. A. (2016). Cognitive and mood functioning in borderline and schizotypal personality disorders. Psychology, 7, 292-299. https://www.doi.org/10.4236/psych.2016.73032

Hamilton, H. K., Sun, J. C., Green, M. F., Kee, K. S., Lee, J., Sergi, M., Sholty, G. L., Mathis, K. I., Jetton, C., Williams, T. J., Kern, R., Horan, W., Fiske, A., Subotnik, K. L., Hellemann, G., Brekke, J., Nuechterlein, K. H., & Yee, C. M. (2014). Social cognition and functional outcome in schizophrenia: The moderating role of cardiovascular flexibility. Journal of Abnormal Psychology, 123, 764-770. https://doi.org/10.1037/a0037813

Ketay, S., Hamilton, H. K., Haas, B. W., & Simeon, D. (2014). Face processing in depersonalization: An fMRI study of the unfamiliar self. Psychiatry Research: Neuroimaging, 222, 107-110. https://doi.org/10.1016/j.pscychresns.2014.02.003

Amodio, D. M. & Hamilton, H. K. (2012). Intergroup anxiety effects on implicit racial evaluation and stereotyping. Emotion, 12, 1273-1280. https://doi.org/10.1037/a0029016

Bartz, J., Simeon, D., Hamilton, H. K., Kim, S., Crystal, S., Braun, A., Vicens, V. & Hollander, E. (2011). Oxytocin can hinder trust and cooperation in borderline personality disorder. Social Cognitive and Affective Neuroscience, 6, 556-563. https://doi.org/10.1093/scan/nsq085

Simeon, D., Bartz, J. Hamilton, H. K., Braun, A., Crystal, S., Ketay, S., & Hollander, E. (2011). Oxytocin administration attenuates stress reactivity in borderline personality disorder: A pilot study. Psychoneuroendocrinology, 36, 1418-1421. https://doi.org/10.1016/j.psyneuen.2011.03.013

Goldstein, K. E., Hazlett, E. A., Savage, K. R., Berlin, H. A., Hamilton, H. K., Zelmanova, Y., Look, A. E., Koenigsberg, H. W., Mitsis, E. M., Tang, C. Y., McNamara, M., Siever, L. J., Cohen, B. H., & New, A. S. (2011). Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder. Behavioural Brain Research, 218, 335-340. https://doi.org/10.1016/j.bbr.2010.11.042

Berlin, H. A., Hamilton, H. K., & Hollander, E. (2008). Experimental therapeutics for refractory obsessive compulsive disorder: Translational approaches and new somatic developments. Mount Sinai Journal of Medicine, 75, 174-203. https://doi.org/10.1002/msj.20045